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Hemoglobin C : ウィキペディア英語版
Hemoglobin C

Hemoglobin C (abbreviated as ''Hb C'' or ''HbC'') is an abnormal hemoglobin in which substitution of a glutamic acid residue with a lysine residue at the 6th position of the β-globin chain has occurred (E6K substitution).〔() 〕
==Clinical significance==
This mutated form reduces the normal plasticity of host erythrocytes causing a hemoglobinopathy. In those who are heterozygous for the mutation, about 28–44% of total hemoglobin (Hb) is HbC, and no anemia develops.
In homozygotes, nearly all Hb is in the HbC form, resulting in mild hemolytic anemia

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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